May 25, 2011

« Gene sequences are — from the point of view of information — one-dimensional. The nucleotide sequence of a gene enciphers directly the amino acid sequence of a protein; and the amino acid sequence is still one-dimensional. But it is the three-dimensional structures of proteins that confer on them their biological activities. The structure arises in a spontaneous folding process by which the amino acid chain takes up its native conformation. This is the point where Nature makes the leap from the 1-dimensional world of sequences to the 3-dimensional world we inhabit. » ~ Lesk

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